https://jeffparoddy.com/AI, health and longevity. Evidence, not hype.en-ushttps://jeffparoddy.com/articles/starlink-ukraine-speed-cap-who-controls/https://jeffparoddy.com/articles/starlink-ukraine-speed-cap-who-controls/Wed, 14 Oct 2026 12:00:00 +0000ScienceKyiv blames SpaceX, Musk points to Washington, and Eutelsat jumped about 23% in Paris. The fight over one speed limit exposes who really controls the satellites.https://jeffparoddy.com/articles/social-security-cola-2027-cpi-w/https://jeffparoddy.com/articles/social-security-cola-2027-cpi-w/Wed, 14 Oct 2026 12:00:00 +0000EconomyThe legal formula averages July to September, so September's gasoline spike counts for only a third, and the Medicare premium that trims the raise is not set yet.https://jeffparoddy.com/articles/auf1-muscle-injury-mice/https://jeffparoddy.com/articles/auf1-muscle-injury-mice/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityMice kept near normal strength after a severe muscle injury when given extra AUF1, by virus or by mRNA. Two authors cofounded the company developing it, and no human has received it.https://jeffparoddy.com/articles/deucrictibant-oral-hae-attacks/https://jeffparoddy.com/articles/deucrictibant-oral-hae-attacks/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityA crossover trial in a rare disease, funded by the drugmaker: each patient treated one attack with the pill and one with placebo. The result is large and the analysis smaller than the enrollment.https://jeffparoddy.com/articles/solengepras-parkinsons-arise/https://jeffparoddy.com/articles/solengepras-parkinsons-arise/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityA new mechanism, a positive primary endpoint and a modest effect size. Everything here comes from a company release and a congress talk, not a peer reviewed paper.https://jeffparoddy.com/articles/long-covid-revive-retraction/https://jeffparoddy.com/articles/long-covid-revive-retraction/Wed, 14 Oct 2026 12:00:00 +0000Evidence GuidesA dose cut and an early stop were applied in the trial but left out of the analysis. The fix downgraded one drug and left the other untouched.https://jeffparoddy.com/articles/iambic-s1-ai-drug-ipo/https://jeffparoddy.com/articles/iambic-s1-ai-drug-ipo/Wed, 14 Oct 2026 12:00:00 +0000AI at WorkOne drug in early clinical testing, a $245 million accumulated deficit, and a platform the company itself calls unproven. The prospectus is more candid than the headlines.https://jeffparoddy.com/articles/fda-decisions-q4-2026/https://jeffparoddy.com/articles/fda-decisions-q4-2026/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityEvery date below comes from the company itself. CagriSema has no published goal date, only a quarter. One file arrives after an advisory committee voted 9 to 3 against.https://jeffparoddy.com/articles/anthropic-life-sciences-claims/https://jeffparoddy.com/articles/anthropic-life-sciences-claims/Wed, 14 Oct 2026 12:00:00 +0000AI at WorkFour launches in three months. One produced a preprint about an enzyme system whose function is still unknown. The rest are access rules, pilots and promises.https://jeffparoddy.com/articles/home-blood-pressure-arm-position/https://jeffparoddy.com/articles/home-blood-pressure-arm-position/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityLap: +3.9 mmHg systolic. Arm at your side: +6.5. A randomized trial measured the couch error, and the fix is a table and five quiet minutes.https://jeffparoddy.com/articles/semaglutide-heart-benefit-beyond-weight/https://jeffparoddy.com/articles/semaglutide-heart-benefit-beyond-weight/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityKnown risk factors explain at most about half of the 20% drop in heart events, and the frailest patients still benefit. Widening eligibility to a BMI of 25 is a different question.https://jeffparoddy.com/articles/orforglipron-menopause-stages/https://jeffparoddy.com/articles/orforglipron-menopause-stages/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityWomen lost 12.8% to 14.4% of their weight on the top dose without diabetes. The diabetes trial tells a shakier story, built partly on a subgroup of 10 women.https://jeffparoddy.com/articles/weekly-insulin-efsitora-approval/https://jeffparoddy.com/articles/weekly-insulin-efsitora-approval/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityEfsitora matched daily insulin on HbA1c in four trials and trades 365 injections for 52. In type 1 diabetes, severe lows were three times as common, which is why the label stops at type 2.https://jeffparoddy.com/articles/insulin-pumps-mint-omnipod-eversense/https://jeffparoddy.com/articles/insulin-pumps-mint-omnipod-eversense/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityOmnipod 5 users kept 4.3 extra hours a day in range for a year. Beta Bionics' Mint is cleared but launches in 2027, and its new algorithm still awaits the FDA.https://jeffparoddy.com/articles/eating-window-8-vs-9-hours/https://jeffparoddy.com/articles/eating-window-8-vs-9-hours/Wed, 14 Oct 2026 12:00:00 +0000Body & LongevityShorter windows meant a few more pounds lost over months. Against a dietitian, a 9 hour window did no better on blood sugar, and both groups lost the same weight.https://jeffparoddy.com/articles/reset-remission-early-type-2-diabetes/https://jeffparoddy.com/articles/reset-remission-early-type-2-diabetes/Wed, 14 Oct 2026 12:00:00 +0000Body & Longevity27 of 50 reached remission in 24 weeks, against 2 of 46 on usual care, and they lost fat without losing lean mass. A 1.6 million patient study shows the stakes of waiting.https://jeffparoddy.com/articles/self-replicating-ai-tv-boxes/https://jeffparoddy.com/articles/self-replicating-ai-tv-boxes/Wed, 14 Oct 2026 12:00:00 +0000AI at WorkOne open model copied itself across a test network with a deliberately easy exploit. The claim that small models will match it by year end rests on a trend line.https://jeffparoddy.com/articles/ai-epilepsy-monitor-false-alarms/https://jeffparoddy.com/articles/ai-epilepsy-monitor-false-alarms/Wed, 14 Oct 2026 12:00:00 +0000AI at WorkPatient feedback retrained a seizure detector and cut false alarms by a median 77.8% in 13 inpatients. The retraining was tested in a replay, not live.https://jeffparoddy.com/articles/artemis-ii-moon-not-gray/https://jeffparoddy.com/articles/artemis-ii-moon-not-gray/Tue, 13 Oct 2026 12:00:00 +0000ScienceThree astronauts spotted five pinprick impact flashes during an eclipse, and described a Moon tinted brown, green and blue. A preliminary report.https://jeffparoddy.com/articles/anthropic-distillation-defenses/https://jeffparoddy.com/articles/anthropic-distillation-defenses/Tue, 13 Oct 2026 12:00:00 +0000AI at WorkA copy trained on Claude's full reasoning scored 80.4% on a coding test, 71.8% on summaries. Anthropic says theft is down 90 to 99%, by its own count.https://jeffparoddy.com/articles/brain-training-dementia-active-trial/https://jeffparoddy.com/articles/brain-training-dementia-active-trial/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityOne arm of a 1990s trial saw fewer dementia diagnoses over 20 years. Five others did not, and the statistics are being argued in public.https://jeffparoddy.com/articles/k2-18b-life-signal-explained/https://jeffparoddy.com/articles/k2-18b-life-signal-explained/Tue, 13 Oct 2026 12:00:00 +0000ScienceA three sigma hint of dimethyl sulfide made headlines. Most independent reanalyses of the same data don't find it, and the gas exists on a comet too.https://jeffparoddy.com/articles/ai-entry-level-jobs-first-rung/https://jeffparoddy.com/articles/ai-entry-level-jobs-first-rung/Tue, 13 Oct 2026 12:00:00 +0000AI at WorkEmployment of 22 to 25 year olds in the most AI exposed jobs sits 19% below trend. The cause is fewer hires, not more layoffs.https://jeffparoddy.com/articles/nvidia-530-billion-commitments/https://jeffparoddy.com/articles/nvidia-530-billion-commitments/Tue, 13 Oct 2026 12:00:00 +0000EconomyThree tables add up to $530 billion. Most of it is a shopping list. The part worth watching is a $105 billion guarantee for one OpenAI site.https://jeffparoddy.com/articles/marine-snow-viscosity-carbon/https://jeffparoddy.com/articles/marine-snow-viscosity-carbon/Tue, 13 Oct 2026 12:00:00 +0000ScienceBacteria struggle to break into the gooiest marine snow, so it sinks deeper. The headline sixfold carbon figure comes from simulations, not the sea.https://jeffparoddy.com/articles/milky-way-antimatter-escape/https://jeffparoddy.com/articles/milky-way-antimatter-escape/Tue, 13 Oct 2026 12:00:00 +0000ScienceFaint 511 keV hotspots match gas clouds beyond the galaxy. If real, the Milky Way makes even more antimatter than anyone can explain. If.https://jeffparoddy.com/articles/nobel-economics-hall-woodford/https://jeffparoddy.com/articles/nobel-economics-hall-woodford/Tue, 13 Oct 2026 12:00:00 +0000EconomyHall showed why spending changes are unpredictable. Woodford built the model central banks run. Together they explain why the Fed talks so much.https://jeffparoddy.com/articles/google-constellation-nuclear-uprates/https://jeffparoddy.com/articles/google-constellation-nuclear-uprates/Tue, 13 Oct 2026 12:00:00 +0000Science890 MW of new power from upgrades at 11 existing units, first by 2028. The other 2,700 MW in the headline was already on the grid.https://jeffparoddy.com/articles/gentoo-penguins-four-species/https://jeffparoddy.com/articles/gentoo-penguins-four-species/Tue, 13 Oct 2026 12:00:00 +0000ScienceGenomes from ten colonies split the gentoo into four lineages. Three may lose most of their habitat by 2050, masked by one that is thriving.https://jeffparoddy.com/articles/ai-tutor-lowered-grades/https://jeffparoddy.com/articles/ai-tutor-lowered-grades/Tue, 13 Oct 2026 12:00:00 +0000AI at WorkA randomized trial of 2,379 students. The tutor was free, patient, and built on GPT-4o. Grades fell anyway.https://jeffparoddy.com/articles/young-strokes-rising/https://jeffparoddy.com/articles/young-strokes-rising/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityCincinnati counted 2,076 first strokes in adults under 55: the rate rose from 34 to 62 per 100,000. In Oxford, young heart attacks fell over the same years.https://jeffparoddy.com/articles/lpa-horizon-pelacarsen/https://jeffparoddy.com/articles/lpa-horizon-pelacarsen/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityPelacarsen lowered Lp(a) in 8,323 HORIZON patients, but heart attacks and strokes did not fall. Why that gap between biomarker and outcome matters.https://jeffparoddy.com/articles/september-ai-models-benchmarked/https://jeffparoddy.com/articles/september-ai-models-benchmarked/Tue, 13 Oct 2026 12:00:00 +0000AI at WorkGPT-6 Sol got cheaper without getting smarter, Sonnet 5.5 got much smarter but not cheaper at full effort, and Astra 6.1 never shipped.https://jeffparoddy.com/articles/diet-soda-water-switch-trial/https://jeffparoddy.com/articles/diet-soda-water-switch-trial/Tue, 13 Oct 2026 12:00:00 +0000Evidence GuidesIn the SWITCH trial, diet drinkers lost 4.8 kg in two years and water drinkers 3.7 kg, but the way it proved sameness is the real lesson.https://jeffparoddy.com/articles/volunteering-apoe4-cognitive-decline/https://jeffparoddy.com/articles/volunteering-apoe4-cognitive-decline/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityA free behavior, a few hours a week, and a slower slope of decline for the gene that usually steepens it. The data are observational, and the paper says so.https://jeffparoddy.com/articles/oral-pcsk9-pill-apob-target/https://jeffparoddy.com/articles/oral-pcsk9-pill-apob-target/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityA daily tablet now cuts LDL by more than half, while the injectable version of the same drug class was linked to 20% fewer deaths in people with no prior heart attack.https://jeffparoddy.com/articles/what-sleep-trackers-really-measure/https://jeffparoddy.com/articles/what-sleep-trackers-really-measure/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityEvery tracker in the lab studies could tell when people were asleep; none could reliably say how deeply, least of all in older adults and patients.https://jeffparoddy.com/articles/read-health-study-in-5-minutes/https://jeffparoddy.com/articles/read-health-study-in-5-minutes/Tue, 13 Oct 2026 12:00:00 +0000Evidence GuidesSix checks: design, endpoint, absolute effect, population, status and funding, limits. The house method, in the open.https://jeffparoddy.com/articles/retatrutide-viking-monthly-maintenance/https://jeffparoddy.com/articles/retatrutide-viking-monthly-maintenance/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityRetatrutide's 20.8% assumes nobody quit, and Viking's 90% comes from a group of 11. The numbers behind the two biggest obesity drug headlines of September.https://jeffparoddy.com/articles/deep-sleep-tau-alzheimers/https://jeffparoddy.com/articles/deep-sleep-tau-alzheimers/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityAs tau builds in healthy older brains, deep sleep waves stop traveling and memory slips. A strong signal, but nobody yet knows which comes first.https://jeffparoddy.com/articles/offensive-ai-agents-fact-check/https://jeffparoddy.com/articles/offensive-ai-agents-fact-check/Tue, 13 Oct 2026 12:00:00 +0000AI at WorkFour AI agent security stories made September's headlines, and they rest on four very different grades of evidence.https://jeffparoddy.com/articles/diet-exercise-beat-supplements-clocks/https://jeffparoddy.com/articles/diet-exercise-beat-supplements-clocks/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityA Yale analysis of 51 studies finds diet and exercise move aging clocks reliably, if modestly, while over the counter supplements barely register.https://jeffparoddy.com/articles/ai-eye-screening-tanzania-followup/https://jeffparoddy.com/articles/ai-eye-screening-tanzania-followup/Tue, 13 Oct 2026 12:00:00 +0000AI at WorkThe win was not a benchmark score. It was people with sight threatening eye disease actually reaching a specialist, and reaching one weeks sooner.https://jeffparoddy.com/articles/ai-layoffs-by-the-numbers/https://jeffparoddy.com/articles/ai-layoffs-by-the-numbers/Tue, 13 Oct 2026 12:00:00 +0000AI at WorkChallenger counts 120,136 announced cuts blamed on AI in 2026. Federal data counts about 1.6 million layoffs every month. Both numbers are true.https://jeffparoddy.com/articles/ai-oversight-body/https://jeffparoddy.com/articles/ai-oversight-body/Tue, 13 Oct 2026 12:00:00 +0000AI at WorkHinton, Bengio and about 400 colleagues are asking for an international body to oversee the most capable AI systems. A public call, not yet a policy.https://jeffparoddy.com/articles/aprocitentan-precision/https://jeffparoddy.com/articles/aprocitentan-precision/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityAgainst placebo, the endothelin blocker lowered systolic pressure by about 4 mmHg on top of three drugs. New post hoc data on obesity and kidney risk.https://jeffparoddy.com/articles/biological-age-clocks/https://jeffparoddy.com/articles/biological-age-clocks/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityA Yale reanalysis of 12 epigenetic clocks says single clock drops don't reproduce. Then come the claims: GLP-1s, a skin cream, 2 to 3 years younger.https://jeffparoddy.com/articles/cagrisema-eloratzp-vs-tirzepatide/https://jeffparoddy.com/articles/cagrisema-eloratzp-vs-tirzepatide/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityNovo won at the low end of the dose range, 12.4 versus 9.1 percent. Lilly won at the top, 23.3 versus 14.8, and lost up to one patient in four to side effects.https://jeffparoddy.com/articles/glp1-muscle-myostatin-antibodies/https://jeffparoddy.com/articles/glp1-muscle-myostatin-antibodies/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityTrevogrumab and apitegromab saved kilograms of lean tissue in phase 2 trials, but no study has yet shown that it makes anyone stronger.https://jeffparoddy.com/articles/lpa-test-once-in-a-lifetime/https://jeffparoddy.com/articles/lpa-test-once-in-a-lifetime/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityOne blood test for life sounds simple, but this year's research shows the result can move, the risk has no clean cutoff, and no Lp(a) drug has proven it saves hearts.https://jeffparoddy.com/articles/muscle-without-meat-impact/https://jeffparoddy.com/articles/muscle-without-meat-impact/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityTwelve weeks of lifting: vegetarians gained 0.38 kg of limb muscle, omnivores 0.66 kg. The trial could not show the two diets were equivalent.https://jeffparoddy.com/articles/muse-wonder-benchmark/https://jeffparoddy.com/articles/muse-wonder-benchmark/Tue, 13 Oct 2026 12:00:00 +0000AI at WorkMeta's new flagship scores 56 on an independent index, two points behind Claude Opus 5.5. And the stronger model is not the one you can call today.https://jeffparoddy.com/articles/orforglipron-vs-insulin-glargine/https://jeffparoddy.com/articles/orforglipron-vs-insulin-glargine/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityOrforglipron cleared a heart safety bar against insulin glargine, 4.2 versus 5.0 percent, and posted a mortality gap the trial was never built to prove.https://jeffparoddy.com/articles/orforglipron-vs-semaglutide/https://jeffparoddy.com/articles/orforglipron-vs-semaglutide/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevityACHIEVE-3, 1,698 adults, 52 weeks: in the primary analysis HbA1c fell 1.91 points against 1.47. A real head to head, run by one of the duelists.https://jeffparoddy.com/articles/sironax-forge-lm/https://jeffparoddy.com/articles/sironax-forge-lm/Tue, 13 Oct 2026 12:00:00 +0000Body & LongevitySironax's FORGE-LM trial is half enrolled. The endpoint is body composition, which is the right question. Enrollment, though, is not a result.https://jeffparoddy.com/articles/wrist-rhythms-obesity/https://jeffparoddy.com/articles/wrist-rhythms-obesity/Tue, 13 Oct 2026 12:00:00 +0000Body & Longevity809 adults, seven days of wrist sensors: robust temperature rhythms tracked with better metabolic markers, light with lower triglycerides. Association only.