
The First PCSK9 Pill Is Here. The Proof Still Comes From a Shot
A daily tablet now cuts LDL by more than half, while the injectable version of the same drug class was linked to 20% fewer deaths in people with no prior heart attack.
Topic
Lipids, blood pressure and cardiovascular risk: biomarkers on one side, events on the other, and the daylight between them.

A daily tablet now cuts LDL by more than half, while the injectable version of the same drug class was linked to 20% fewer deaths in people with no prior heart attack.

One blood test for life sounds simple, but this year's research shows the result can move, the risk has no clean cutoff, and no Lp(a) drug has proven it saves hearts.

Pelacarsen lowered the biomarker in 8,323 patients. Events did not follow. What that gap teaches about every longevity claim.
Against placebo, the endothelin blocker lowered systolic pressure by about 4 mmHg on top of three drugs. New post hoc data on obesity and kidney risk.
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