Diet and Exercise Moved 16 Aging Clocks. Supplements Didn’t
A Yale analysis of 51 studies finds diet and exercise move aging clocks reliably, if modestly, while over the counter supplements barely register.
Pillar
Longevity
Aging clocks, muscle and the habits that hold up under evidence.
5 articles
Biological Age Claims Need More Than One Clock
A Yale reanalysis of 12 epigenetic clocks says single clock drops don't reproduce. Then come the claims: GLP-1s, a skin cream, 2 to 3 years younger.
Myostatin Blockers Cut GLP-1 Muscle Loss. Strength Is Unproven
Trevogrumab and apitegromab saved kilograms of lean tissue in phase 2 trials, but no study has yet shown that it makes anyone stronger.
Muscle Without Meat After 55: What the IMPACT Trial Found
Twelve weeks of lifting: vegetarians gained 0.38 kg of limb muscle, omnivores 0.66 kg. The trial could not show the two diets were equivalent.
The Race to Keep Muscle on GLP-1s Reaches Phase 2
Sironax's FORGE-LM trial is half enrolled. The endpoint is body composition, which is the right question. Enrollment, though, is not a result.
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